Curcumin is the main polyphenol in curcumin root, responsible for its therapeutic effects. Its antitumor action is very versatile as it has been shown to modulate and influence multiple molecules involved in cancer growth, by altering the expression of cellular genes and influencing cancer signaling pathways.
It has been shown to modulate and influence multiple molecules involved in cancer growth, by altering the expression of cellular genes and influencing cancer signaling pathways.
Scientific studies have shown curcumin's ability to iinhibit the growth of prostate adenocarcinoma cells.
Curcumin increases apoptosis or cell death of tumor cells in prostate cancer.
This antitumor action is present in both hormone-sensitive tumors and in tumors that do not respond to hormone treatment.
Other studies have shown that the combination of curcumin and resveratrol further enhances its antitumor effect in prostate cancer.
In advanced stages of prostate cancer that do not respond to hormonal treatment, the use of derivatives of different plants, such as curcumin, the resveratrol and others, can help prolong survival through inhibitory action on tumor cell growth, and inhibition of metastasis.
Scientific studies on curcumin in the treatment of prostate cancer
- Panahizadeh R, Vatankhah MA et al.(2023). Cytotoxicity of curcumin against CD44± prostate cancer cells: Roles of miR-383 and miR-708. Avicenna J Phytomed. 2023 Jul-Aug;13(4):429-441. doi: 10.22038/AJP.2023.21913. PMID: 37663388; PMCID: PMC10474917.
- Costantini E, Di Nicola M et al. (2022). Effects of Curcumin and Lactoferrin to Inhibit the Growth and Migration of Prostatic Cancer Cells. Int J Environ Res Public Health. 2022 Dec 3;19(23):16193. doi: 10.3390/ijerph192316193. PMID: 36498267; PMCID: PMC9737629.
- Lee YJ, Lee SH. (2022) ERK1/2-Dependent Inhibition of Glycolysis in Curcumin-Induced Cytotoxicity of Prostate Carcinoma Cells. Biomed Res Int. 2022 Aug 24;2022:7626405. doi: 10.1155/2022/7626405. PMID: 36060138; PMCID: PMC9433281.
- Boccellino M, Ambrosio P, Ballini et al (2022). The Role of Curcumin in Prostate Cancer Cells and Derived Spheroids. Cancers (Basel). 2022 Jul 9;14(14):3348. doi: 10.3390/cancers14143348. PMID: 35884410; PMCID: PMC9320241.
- Pan L, Sha J, Lin W, et al. (2021) Guo J. Curcumin inhibits prostate cancer progression by regulating the miR-30a-5p/PCLAF axis. Exp Ther Med. 2021;22(3):969. doi:10.3892/etm.2021.10401
- Nurul Azwa Abd. Wahab et al (2020). Mechanism of Anti-Cancer Activity of Curcumin on Androgen-Dependent and Androgen-Independent Prostate Cancer. Nutrients 2020, 12, 679; doi:10.3390/nu12030679
- Deborah Termini, Danja J. Den Hartogh et al (2020). Curcumin against Prostate Cancer: Current Evidence. Biomolecules 2020, 10, 1536; doi:10.3390/biom10111536.
- Wei Guo, Xia Wu et al (2019). Evaluation of biophysical as well as biochemical potential of curcumin and resveratrol during prostate cancer. Journal of Drug Targeting, DOI: 10.1080/1061186X.2019.1601199
- Shilpa Katta 1,2, Arun Srivastava et al (2019). Curcumin-Gene Expression Response in Hormone Dependent and Independent Metastatic Prostate Cancer Cells. Int. J. Mol. Sci. 2019, 20, 4891; doi:10.3390/ijms20194891
